摘要 :
Breast cancer (BC) is the most common cancer diagnosis in women worldwide. Among causative BC genes, MRE11, ERCC1, TNRC9 (TOX3), and CASC16 play an important role in DNA damage repair; FGFR2, CCNE1, ZMIZ1, and LSP1 involve in cell...
展开
Breast cancer (BC) is the most common cancer diagnosis in women worldwide. Among causative BC genes, MRE11, ERCC1, TNRC9 (TOX3), and CASC16 play an important role in DNA damage repair; FGFR2, CCNE1, ZMIZ1, and LSP1 involve in cell cycle checkpoint. A functional polymorphism of these genes may alter DNA repair capacity and genomic stability. Single Nucleotide Polymorphisms (SNPs) can modify the risk of cancer, and thus, SNPs may be considered as potential markers of carcinogenesis. Among them, eight SNPs (rs2981582, rs569550, rs3218035, rs704010, rs2155209, rs3212986, rs12443621 and rs4784227) are significantly associated with BC risk in various populations. This study was conducted to investigate the genetic susceptibility of these SNPs in the development of BC in Vietnamese women. MRE11 rs2155209 and CASC162 rs4784227 were found to be associated with BC risk (CC vs. CT + TT: OR = 0.57, 95% CI 0.34 to 0.97, P = 0.03 and CT vs. CC + TT: OR = 1.43, 95% CI 1.03 to 1.97, P = 0.03; respectively). These findings suggest that SNPs involved in DNA repair genes may affect the susceptibility of BC in Vietnamese women.
收起
摘要 :
electrocatalysts by enhancing the number of active sites, ligand engineering, and integration of metals and the development of MOFs composites. The electrocatalytic activities of MOF-based catalysts for HER and OER are discussed a...
展开
electrocatalysts by enhancing the number of active sites, ligand engineering, and integration of metals and the development of MOFs composites. The electrocatalytic activities of MOF-based catalysts for HER and OER are discussed along with their stability and selectivity. Overall, MOF-based electrocatalysts have great potential towards the advancement of competent and sustainable electrochemical energy storage and conversion technologies. Finally, a critical discussion of complications and future perspectives of emerging MOFs as electrocatalysts is also highlighted. (c) 2023 Hydrogen Energy Publications LLC. Published by Elsevier Ltd. All rights reserved.
收起
摘要 :
Particulate-bound mercury (PBM) is a global environmental concern owing to its large dry deposition velocities and scavenging coefficients, both of which drive Hg into terrestrial and marine ecosystems. PBM observation studies hav...
展开
Particulate-bound mercury (PBM) is a global environmental concern owing to its large dry deposition velocities and scavenging coefficients, both of which drive Hg into terrestrial and marine ecosystems. PBM observation studies have been widely conducted over East Asia, but comparable studies in Peninsular Southeast Asia (PSEA) remain scarce. This is the first study reporting PBM concentrations for Ho Chi Minh City (HCMC), the biggest metropolitan area in Vietnam. A total of 222 samples were collected in 2018 and contained an average PBM10 (particulate matter - PM with diameter 收起
摘要 :
Carbon-based materials have emerged as an excellent class of biomedical materials due to their exceptional mechanical properties, lower surface friction, and resistance to wear, tear, and corrosion. Experimental studies have shown...
展开
Carbon-based materials have emerged as an excellent class of biomedical materials due to their exceptional mechanical properties, lower surface friction, and resistance to wear, tear, and corrosion. Experimental studies have shown the promising results of carbon-based coatings in the field of biomedical implants. The reasons for their successful applications are their ability to suppress thrombo-inflammatory reactions which are evoked as an immune response due to foreign body object implantation. Different types of carbon coatings such as diamond-like carbon, pyrolytic carbon, silicon carbide, and graphene have been extensively studied and utilized in various fields of life including the biomedical industry. Their atomic arrangement and structural properties give rise to unique features which make them suitable for multiple applications. Due to the specificity and hardness of carbon-based precursors, only a specific type of coating technique may be utilized for nanostructure development and fabrication. In this paper, different coating techniques are discussed which were selected based on the substrate material, the type of implant, and the thickness of coating layer. Chemical vapor deposition-based techniques, thermal spray coating, pulsed laser deposition, and biomimetic coatings are some of the most common techniques that are used in the field of biomaterials to deposit a coating layer on the implant. Literature gathered in this review has significance in the field of biomedical implant industry to reduce its failure rate by making surfaces inert, decreasing corrosion related issues and enhancing biocompatibility.
收起
摘要 :
HNTs have garnered a substantial amount of scientific interest over the years owing to its green nature, unique surface chemistry and the ability to load any guest molecule. These nanostructures are biocompatible and are thus perf...
展开
HNTs have garnered a substantial amount of scientific interest over the years owing to its green nature, unique surface chemistry and the ability to load any guest molecule. These nanostructures are biocompatible and are thus perfect nanocarriers for the delivery of drugs and therapeutic biologics. However, in order to fully achieve its potential as a nanocarrier, several nuances to its surface chemistry and release kinetics must be kept in mind. Factors like the choice of compound for functionalization of HNTs and the microenvironmental pH of the targeted area are obvious yet intricate and crucial to ensure optimum therapeutic effect with minimized side effect profile. This article comprehensively reviews the safety profile of pristine and modified HNTs across different cell lines and model organisms. Furthermore, we also aim to provide an insight into the unique chemistry involved between drugs or biomolecules and the functional moieties on the surface of HNTs, which evidently alters the release rate of these guest molecules. Lastly, this focused review on drug delivery aims at providing critical comments and highlighting unexplored avenues in the current progress of research.
收起
摘要 :
Introduction The utilization and misuse of prescription and controlled medications are expanding globally. However, the kind of substance abused may contrast from one country to another, but few drugs expand their horizons due to ...
展开
Introduction The utilization and misuse of prescription and controlled medications are expanding globally. However, the kind of substance abused may contrast from one country to another, but few drugs expand their horizons due to misused capabilities, expansion of the darknet, and increase in the Internet Connecting World. One of them is tramadol, a widely misused drug worldwide, which enforcement agencies recently noticed. In treating moderate to severe pain, a racemic combination of tramadol is employed. The non-medical utilization of narcotic drugs, i.e., tramadol, is a quick arising general medical issue prompting expanding calls for planning alterations to existing policies, reconnaissance, research, and wellbeing advancement measures. Tramadol addicts typically have a history of substance usage, and studies show that the number of tramadol abusers is increasing, particularly in some Middle Eastern Nations. Method This review article finds the trends of analytical methods toward identification in pharmaceutical preparation and toxicological samples such as hair, urine, blood, and saliva. In the last 20 years, various analytical tools such as UV-visible spectroscopy, HPTLC, HPLC, LC-MS, GC, GC-MS, NMR, Fluorescence Spectroscopy, Capillary Electrophoresis, Electrochemical sensors have been used for the identification of drugs in pharmaceutical preparation and toxicological samples. Forensic Scientists can only rely on quick and easy methods to perform. Result and discussion This evaluation aims to give forensic scientists, pharmaceutical companies, and toxicologists the best solution for identifying tramadol acquired in the chemistry and toxicological divisions of various laboratories.
收起
摘要 :
In this paper, we present a simple route to synthesize PBS/nHAP polymer nanocomposites and share our findings on the influence of nHAP (filler) on the PBS (matrix). The filler weight content was varied from 0.0 g to 0.10 g. These ...
展开
In this paper, we present a simple route to synthesize PBS/nHAP polymer nanocomposites and share our findings on the influence of nHAP (filler) on the PBS (matrix). The filler weight content was varied from 0.0 g to 0.10 g. These effects that were investigated were the structural, morphological, mechanical, wettability, and roughness parameters. The X-ray Diffraction (XRD) spectra revealed that PBS and nHAP produced their separate phases. The Scanning Electron Microscopy (SEM) results display pores in the Neat PBS while pores are filled in the PBS/nHAP polymer nanocomposites. Further increase in the filler content revealed that agglomeration began to occur, and it permeated out of the pores and onto the surface imparting brittleness to the composite. The mechanical results confirm the increase in tensile strength up to a certain point of nHAP-5. The wettability studies prove that by increasing the filler weight content, the hydrophobic nature converts to a moderate hydrophilic nature. The roughness studies revealed the roughness values of the PBS/nHAP composites to be higher than that of Neat PBS.
收起
摘要 :
Studying the concentration of radioactive lead in soil and plants, and using plants for phytoremediation are important for the environment and human health protection. In this study, we used gamma spectrometry to determine activit...
展开
Studying the concentration of radioactive lead in soil and plants, and using plants for phytoremediation are important for the environment and human health protection. In this study, we used gamma spectrometry to determine activity concentration in soil - plants, transfer factor. The average activity concentration of lead radionuclides in soil and plants were in the following order of 210Pb > 214Pb > 212Pb. The average activity ratio of 214Pb and 212Pb to 210Pb in soil were 0.70 and 0.59 and in plants were 0.69 and 0.14, respectively. The results showed that there was not much difference between the ratio of radioactive 214Pb and 210Pb concentrations in vegetable and plant samples. Ming aralia (Polyscias fruticose) and lettuce (Lactuca sativa) contained the highest concentrations of 210Pb, and Malabar spinach (Basella alba) contained the lowest concentration. Ming aralia could be used for the radioactive decontamination of 210Pb. There vegetable samples from Ho Chi Minh City were considered safe for human consumption in the aspect of lead radionuclides.
收起
摘要 :
Objective. Recently, many electrocardiogram (ECG) classification algorithms using deep learning have been proposed. Because the ECG characteristics vary across datasets owing to variations in factors such as recorded hospitals and...
展开
Objective. Recently, many electrocardiogram (ECG) classification algorithms using deep learning have been proposed. Because the ECG characteristics vary across datasets owing to variations in factors such as recorded hospitals and the race of participants, the model needs to have a consistently high generalization performance across datasets. In this study, as part of the PhysioNet/Computing in Cardiology Challenge (PhysioNet Challenge) 2021, we present a model to classify cardiac abnormalities from the 12- and the reduced-lead ECGs. Approach. To improve the generalization performance of our earlier proposed model, we adopted a practical suite of techniques, i.e. constant-weighted cross-entropy loss, additional features, mixup augmentation, squeeze/excitation block, and OneCycle learning rate scheduler. We evaluated its generalization performance using the leave-one-dataset-out cross-validation setting. Furthermore, we demonstrate that the knowledge distillation from the 12-lead and large-teacher models improved the performance of the reduced-lead and small-student models. Main results. With the proposed model, our DSAIL SNU team has received Challenge scores of 0.55, 0.58, 0.58, 0.57, and 0.57 (ranked 2nd, 1st, 1st, 2nd, and 2nd of 39 teams) for the 12-, 6-, 4-, 3-, and 2-lead versions of the hidden test set, respectively. Significance. The proposed model achieved a higher generalization performance over six different hidden test datasets than the one we submitted to the PhysioNet Challenge 2020.
收起
摘要 :
Anode-free lithium metal batteries (AFLMBs) can achieve a high energy density. However, achieving high -capacity retention and Coulombic efficiency (CE) are challenging without a continuous Li supply from the Cu anode side. The lo...
展开
Anode-free lithium metal batteries (AFLMBs) can achieve a high energy density. However, achieving high -capacity retention and Coulombic efficiency (CE) are challenging without a continuous Li supply from the Cu anode side. The lower CE and rapid capacity decay in AFLMBs are primarily due to non-uniform Li deposition and electrolyte decomposition during cycling. Herein, strontium fluoride (SrF2) nanoparticles are applied on Cu foils to attain the in-situ forming of a bifunctional interfacial layer, a Li-Sr alloy, and a LiF-rich SEI composite layer during Li plating. The derived Cu@SrF2 electrode has excellent plating/stripping stability and outstanding performance. AFLMB full cell (Cu@SrF2//NCM111) attains an average Coulombic efficiency (ACE) of 98.6 % and capacity retention of 51.0 % at the 60th cycle using a commercial carbonate-based electrolyte. In contrast, the bare AFLMB full cell (BCu//NCM111) only has an ACE of 94.9 % with a capacity retention of 10.2 % under the same conditions. The concept is proven in lithium metal batteries (LMBs). This strategy provides a simultaneous Li nucleation and formation of LiF-rich SEI layers, rendering it promising to realize AFLMBs and LMBs with long lifespans and high CE.
收起
原文获取